Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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The Chemopreventive Mechanism of Selenium: Selenomethionine Regulation of P53 Activation

  • Jung, Hwa-Jin (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Yim, Sung-Vin (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Park, Seungjoon (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Jung, Joo-Ho (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Jung, Jee-Chang (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Seo, Young-Rok (Department of Pharmacology, College of Medicine, Kyung Hee University, Corresponding author)
  • Published : 2003.10.01
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Abstract

Recently, selenium has been reported to have cancer-preventive properties, although the mechanism is little known. To elucidate the mechanism, we examined the effect of selenomethionine (SeMet) on the functional status of p53. Here we show the activation of p53 tumor suppressor in the presence of SeMet without DNA damage. (omitted)

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