한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2003년도 추계학술대회
- /
- Pages.155-156
- /
- 2003
A Pharmacogenomic Study on Regional Dependent gene Expression and Drug Permeability in Rat Intestine
- Shin, Ho-Chul (Dept. of Pharmacokinetics and Toxicokinetics, Korea Institute of Toxicology) ;
-
Chung, Moon-Koo
(Dept. of Pharmacokinetics and Toxicokinetics, Korea Institute of Toxicology)
;
- Han, Sang-Seop (Dept. of Pharmacokinetics and Toxicokinetics, Korea Institute of Toxicology) ;
- Duxin Sun (Dept. of Pharmaceutical Sciences, University of Michigan) ;
- Gordon L. Amidon (Dept. of Pharmaceutical Sciences, University of Michigan)
- 발행 : 2003.10.01
초록
RNA was isolated from mucosal tissue of the duodenum, jejunum, ileum and colon after perfusion. The gene expression profiles were measured using Affymetrix GeneChip(R) analysis. Prodrug valacyclovir permeability was 5-fold and 2-fold higher than the parent drug acyclovir in the jejunum and ileum, respectively.(omitted)