Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Inhibition of Cytokine Induced I-$textsc{k}$B Kinase Activation as a Mechanism Contributing to the Anti-Atherogenic Activity of Tilianin in Hyperlipidemic Mice

  • Nam, Kung-woo (Natural Products Research Institute, Seoul National University) ;
  • Kim, Jiyun (Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology) ;
  • Hong, Jung-Joo (Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology) ;
  • Park, Jae-Hoon (Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology) ;
  • Woonchon Mar (Natural Products Research Institute, Seoul National University) ;
  • Cho, Myung-Haing (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Young-Myeong (Vascular System Research Center, Kangwon National University) ;
  • Oh, Sei-Ryang (Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology) ;
  • Nam, Ki-Hoan (Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2003.10.01
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Abstract

In previous study, we demonstrated tilianin inhibits tumor necrotic factor-${\alpha}$ (TNF-${\alpha}$) induced vascular cell adhesion molecule-1 (VCAM-1) expression in human umbilical vein endothelial cells (HUVEC). In this study, we demonstrate inhibition of the production of atherogenic cytokines and the anti-atherogenic effects of tilianin in Ldlr-/- mice.(omitted)

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