Therapeutic Efficacy of YCY on CCl4-induced Liver Dysfunction in Rats

  • 발행 : 2003.10.01

초록

Carbon tetrachloride (CCl4) is known to cause liver injury characterized by centrilobular necrosis. The toxicity is thought to be exerted via cytochrome P-450-mediated metabolism of $CCl_4$ to trichloromethyl and trichloro-methylperoxy radicals, which initiates lipid peroxidation, leading to hepatocellular membrane damage [l, 2]. Our study demonstrates a therapeutic efficacy of YCY, extract of a cricket, Gryllus bimaculatus, on liver injuries induced by $CCl_4$. (omitted)

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