대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.130.1-130.1
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- 2003
Metabolism of YH3945, a novel anticancer drug, in rats using 14C-labeled compound
- Lee, Jae-Ick (Korea Institute of Science and Technology) ;
- Son, Jung-Hyun (Yuhan Research Institut) ;
- Ahn, Byung-Nak (Yuhan Research Institut) ;
- Lee, Bong-Yong (Yuhan Research Institut) ;
- Kim, Dong-Hyun (Yuhan Research Institute)
- 발행 : 2003.04.01
초록
The metabolism of a novel anticancer agent 1-{3- [3-(4-Cyano -benzyl)-3H-imidazol-4-yl]-propyl }-3-(6-methoxy-pyridin-3-yl)-1-(2-trifluoromethyl-benzyl)-thiourea (YH3945) were investigated in the Sprague-Dawley rat after single oral and i.v. administration of [14C]-YH3945. Bile, feces, urine and plasma were collected and analyzed by an HPLC system equipped with multiple detectors. (omitted)
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