Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.130.3-131
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- 2003
The effects of the novel IDPc inhibitor, DA-11004, on NADPH generation, insulin secretion, and glucose level in zucker rats
- Shin, Chang-Yell (Research Laboratories, Dong-A Pharm, Co. Ltd.) ;
- Jeong, Mi-Young (Research Laboratories, Dong-A Pharm, Co. Ltd) ;
- Sohn, Jin-Bup (Research Laboratories, Dong-A Pharm, Co. Ltd) ;
- Lee, In-Ki (Research Laboratories, Dong-A Pharm, Co. Ltd) ;
- Son, Mi-Won (Research Laboratories, Dong-A Pharm, Co. Ltd) ;
- Bae, Cheol-Jun (Research Laboratories, Dong-A Pharm, Co. Ltd) ;
- Byun, Jong-Soo (Research Laboratories, Dong-A Pharm, Co. Ltd) ;
- Kim, Dong-Sung (Research Laboratories, Dong-A Pharm, Co. Ltd) ;
- Kim, Soon-Hae (Research Laboratories, Dong-A Pharm, Co. Ltd.)
- Published : 2003.04.01
Abstract
The biological effects of NADPH-dependent isocitrate dehydrogenase (IDPc) inhibitor. DA-11004, was examined in obese zucker rats or streptozotocin-induced diabetic SD rats. Diabetes was induced by injection of streptozotocin (50mg/kg) dissolved in citrate buffer (pH 4.8) into the tail vein and induction of diabetes was confirmed by the measurement of the tail blood glucose level at 48h. DA-11004 (30mg/kg, po) was injected for successive 7days and significantly reduced the plasma glucose in streptozotocin-induced diabetic rats (P<0.05). (omitted)
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