대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.131-131
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- 2003
KR-32158 protects heart-derived H9c2 cells from oxidative stress-induced cell death
- Kim, Mi-Jeong (Department of Physiology, Ajou university School of Medicine) ;
- Jung, Yi-Sook (Bioorganic Division, Korea Research of Chemical Technolog) ;
- Kim, Sun-Ok (Bioorganic Division, Korea Research of Chemical Technolog) ;
- Lee, Dong-Ha (Bioorganic Division, Korea Research of Chemical Technolog) ;
- Lim, Hong (Bioorganic Division, Korea Research of Chemical Technolog) ;
- Yi, Kyu-Yang (Bioorganic Division, Korea Research of Chemical Technolog) ;
- Yoo, Sung-Eun (Bioorganic Division, Korea Research of Chemical Technolog) ;
- Lee, Soo-Hwan (Bioorganic Division, Korea Research of Chemical Technolog) ;
- Baik, Eun-Joo (Bioorganic Division, Korea Research of Chemical Technology)
- 발행 : 2003.04.01
초록
A benzopyranyl derivative, KR32158, synthesized as a plausible KATP opener, has been shown to exert cardioprotective effect in vivo myocardial infarction model. Myocardial ischemia, induced by oxidative stress, mental stress and fever, result in artheroscleosis, myocardial infarction and hypertrophy. In this study, we investigated in vitro effect of KR32158 by determining whether KR32158 produce cardioprotective effect against oxidative stress-induced death in heart-derived H9c2 cells. (omitted)
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