대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.133.1-133.1
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- 2003
OST -5440, A Small Molecule Inhibitor of Human Cathepsin K, Inhibits Bone Resorption In Vivo as well as In Vitro
- Kim, H.D. (Research Laboratories, Dong-A Pharmaceutical Co., Ltd.) ;
- Park, J.H. (Yuhan Research Institut) ;
- Lee, S.S. (Yuhan Research Institut) ;
- H, Son-M. (Yuhan Research Institut) ;
- Y, Kwak-W. (Yuhan Research Institut) ;
- S, Yang-J. (Yuhan Research Institut) ;
- I, Lim-J (Yuhan Research Institut) ;
- Kim, S.H. (Yuhan Research Institut) ;
- Kim, W.B. (Yuhan Research Institute)
- 발행 : 2003.04.01
초록
Cathepsin K (CK) is a cysteine protease that plays a major and essential role in osteoclast-mediated degradation of collagen matrix of bone. Its tissue-limited distribution and pivotal contribution to bone resorption meet the requirements as the potential therapeutic target of the disease with excessive bone loss such as osteoporosis. In a search for potent CK inhibitors. we found OST-5440 that effectively inhibited bone resorption in vivo as well as in vitro. (omitted)
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