Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Enantio-Selective Inhibition of (1R,9S)- and (1S,9R)-$\beta$-Hydrastines on Dopamine Biosynthesis in PC12 Cells

  • Yin, Shou-Yu (College of Pharmacy, Yanbian University) ;
  • Kim, Yu-Mi (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University) ;
  • Lee, Jae-Joon (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University) ;
  • Jin, Chun-Mei (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University) ;
  • Yang, You-Jong (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University) ;
  • Kang, Min-Hee (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University) ;
  • Lee, Myung-Koo (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University)
  • Published : 2003.04.01
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Abstract

The inhibitory effects of (1R, 9S)- and (1S, 9R)-enantiomers of $\beta$-hydrastine (BHS) on dopamine biosynthesis in PC12 cells were investigated. (1R, 9S)-BHS decreased the intracellular dopamine content with the $IC_{50}$ value of 14.3 $\mu\textrm{M}$ at 24 h, but (1S, 9R)-BHS did not. In these conditions, (1R, 9S)-BHS inhibited TH activity mainly in a concentration-dependent manner(33％ inhibition at 20 $\mu\textrm{M}$) and decreased TH mRNA level. (omitted)

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