Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.149.3-150
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- 2003
Importance of Cytochrome P450 3A4 Conformation for the Activity Stimulation by Cytochrome b5 : Specific Inhibition of Cytochrome P450 3A4 by Zinc (II) Ion
- Kim, Joon-Sik (AngioLab and Division of Life Sciences, Pai-Chai University) ;
- Yun, Chul-Ho (AngioLab and Division of Life Sciences, Pai-Chai University)
- Published : 2003.04.01
Abstract
CYP3A4 is the most abundant human CYP and oxidizes a diversity of substrates. including various drugs. steroids. and carcinogens. A variety of metal ions are known to affect microsomal monooxygenase activities. Effects of a series of divalent metal ions on the CYP3A4-catalyzed reaction of reconstituted system containing purified CYP3A4. NADPH-P450 reductase (NPR), and cytochrome b5 (b5) were examined. (omitted)
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