Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
- /
- Pages.150-151
- /
- 2003
Increase of susceptibility against apoptotic stimuli in PC12 cells carrying mutant PS2 : Increase of p53 mRNA level. 8-oxo-dG formation and NF-$\kappa$ B activation
- Nguyen, Hong-Nga (College of Pharmacy, Chungbuk National University) ;
- Lee, Sun-Young (College of Pharmacy, Chungbuk National University) ;
- Shin, Im-Chul (College of Pharmacy, Chungbuk National University) ;
- Kim, Young-Kyu (Korea Food and Drug Administratio) ;
- Hwang, Dae-Yeun (Korea Food and Drug Administratio) ;
-
Hong, Jin-Tae
(College of Pharmacy, Chungbuk National University)
- Published : 2003.04.01
Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognition and memory in association with widespread neuronal loss. AD is supposed to be very often associated with missense mutation located on homologous protein Presenilin (PS1) and (PS2). Up to now, the molecular mechanisms underlying the role of the gene mutation in AD still remain unclear. (omitted)
Keywords