Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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EFFECTS OF CADMIUM CHLORIDE ON GLUCOSE TRANSPORT IN 3T3-L1 ADIPOCYTES

  • Kim, M.H. (Lab of hygienic chemistry, college of pharmacy, Seoul National University) ;
  • Kim, K.S. (Lab of hygienic chemistry, college of pharmacy, Seoul National University) ;
  • Lee, H.B. (Lab of hygienic chemistry, college of pharmacy, Seoul National University) ;
  • Chae, S.H. (Lab of hygienic chemistry, college of pharmacy, Seoul National University) ;
  • Jung, A.Y. (Lab of hygienic chemistry, college of pharmacy, Seoul National University) ;
  • Jo, Y.Y. (Lab of hygienic chemistry, college of pharmacy, Seoul National University) ;
  • Kim, M.H. (Lab of hygienic chemistry, college of pharmacy, Seoul National University) ;
  • Moon, C.K. (Lab of hygienic chemistry, college of pharmacy, Seoul National University)
  • Published : 2003.04.01
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Abstract

Cadmium is well known as a toxic metal and has insulin mimicking effects in rat adipose tissue. To investigate the effect of CdCl2 on glucose transport and its mechanism, this study was performed in 3T3-L1 adipocytes. 10 and 25mM of CdCl2 exposed to cells for 12 hours increased 2-deoxyglucose uptake to 2.2 and 2.8 fold, respectively. Nifedipine, a calcium channel blocker, inhibited the 2-deoxyglucose uptake stimulated by CdCl2. (omitted)

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