Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.185.1-185.1
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- 2003
Cadmium altered zinc homeostasis in the Neuronal Cell
- Ahn, Sung-Hee (Department of Environmental Health Science, College of Natural Science, Soonchunhyang University) ;
- Jang, Bong-Ki (Department of Environmental Health Science, College of Natural Science, Soonchunhyang University) ;
- Park, Jong-An (Department of Environmental Health Science, College of Natural Science, Soonchunhyang University) ;
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Lee, Jong-Wha
(Department of Environmental Health Science, College of Natural Science, Soonchunhyang University)
- Published : 2003.04.01
Abstract
In this study, we investigated the effect of cadmium on genes expression related to zinc homeostasis in HT22 hippocampal neuron cell line by RT -PCR and western blotting technics. In the time-course effect, cadmium up-regulated the relative levels of MT -I and MT -II to~b-actin at 4 hr after treatment. These effects were consistent with MT -I/II protein contents by western blot analysis. But MT -III, a specific MT isoform in brain, was not affected by cadmium. (omitted)
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