Identification of Differentially Expressed Genes by Methylmercury in Neuroblastoma cell line using suppression subtractive hybridization (SSH) and cDNA Microarray

  • Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
  • Chang, Suk-Tai (Toxicology Laboratory, Korea Institute of Science & Technolog) ;
  • Yun, Hye-Jung (Toxicology Laboratory, Korea Institute of Science & Technolog) ;
  • Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science & Technology)
  • Published : 2003.04.01

Abstract

Methylmercury (MeHg), one of the heavy metal compounds. can cause severe damage to the central nervous system in humans. Many reports have shown that MeHg is poisonous to human body through contaminated foods and has released into the environment. Despite many studies on the pathogenesis of MeHg-induced central neuropathy, no useful mechanism of toxicity has been established so far. (omitted)

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