Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Histamine Signaling Pathway in Sensory Neurons is Similar to Bradykinin

  • Lee, Sang-Hee (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
  • Koo, Jae-Yeon (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
  • Kim, Sang-Sung (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
  • Lee, Jung-Youn (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
  • Cho, Ha-Won (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
  • Kim, Byung-Moon (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
  • Oh, Uh-Taek (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University)
  • Published : 2003.04.01
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Abstract

Histamine is found in most tissues of the body and activates polymodal nociceptors via unmyelinated afferent C-fibres. We have demonstrated that bradykinin. acting at B2 bradykinin receptors. excites sensory nerve endings by activating capsaicin receptors via production of 12-lipoxygenase metabolites of arachidonic acid in dorsal root ganglion. Histamine is known to the activator of phospholipase A2- arachidonic acid pathway via a G-protein- coupled H1 receptor. (omitted)

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