대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.202.1-202.1
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- 2003
Effects of Ginsenoside Rg1 on the Expression of TNF-$\alpha$ from Rat microglia
- Joo, Seong-Soo (Department of Immunology, College of Pharmacy, Chung-Ang University) ;
- Won, Tae-Joon (Department of Immunology, College of Pharmacy, Chung-Ang University) ;
- Lee, Do-Ik (Department of Immunology, College of Pharmacy, Chung-Ang University)
- 발행 : 2003.04.01
초록
Microglial cell can act for phagocytosis against abnormal particles in brain, which means that beta-amyloid produced from APP(amyloid precursor protein) can be phagocytosed by microglia when released. In contrast. when senile plaque has already been formed in brain cortex and hippocamphal region, microglia can also accelerate the AD pathogenesis due to chronic inflammatory action, which lead to neuron cell cytotoxicity. (omitted)
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