Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.223.1-223.1
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- 2003
Roles of Phosphatidylinositol 3-Kinase(PI3K) and Rac1
- Shin, Il-Chung (College of Pharmacy, Duksung Women′s University) ;
- Kim, Seon-Hoe (College of Pharmacy, Duksung Women′s University) ;
- Moon, A-Ree (College of Pharmacy, Duksung Women′s University)
- Published : 2003.04.01
Abstract
Many studies have identified the phosphatidylinositol 3-kinase (PI3K) as a key regulator for various cellular functions including cell survival, growth and motility. We have previously shown that H-ras, but not N-ras. induces invasiveness and motility in human breast epithelial cells (MCF10A), while both H-ras and N-ras induce transformed phenotype. In the present study, we wished to investigate the functional role of PI3K pathway in H-ra-induced invasive phenotype and motility of MCF10A cells. (omitted)
Keywords