Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.233.1-233.1
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- 2003
Structural Requirement of New Chalcones for the Inhibitory Activity of Interleukin-5
- Cho, Soo-Hyun (College of Pharmacy, Chungnam National University) ;
- Yang, Hyun-Mo (College of Pharmacy, Chungnam National University) ;
- The, Hung-Dang (College of Pharmacy, Chungnam National University) ;
- Ju, Jung-Hun (College of Pharmacy, Chungnam National University) ;
- Kim, Mi-Kyung (College of Pharmacy, Chungnam National University) ;
- Lee, Seung-Ho (College of Pharmacy, Chungnam National University) ;
- Ryu, Jae-Chun (College of Pharmacy, Chungnam National University) ;
- Kim, Young-Soo (College of Pharmacy, Chungnam National University) ;
- Jung, Sang-Hun (College of Pharmacy, Chungnam National University)
- Published : 2003.04.01
Abstract
Interleukin (IL)-5 appears to be one of the main proinflammatory mediators among a growing number of cytokines and chemokines that induce eosinophilic inflammation. Sophoricoside and their analogs isolated from Sophora japonica show relatively potent inhibitory activity of interleukin (IL)-5 as a small molecule. Initial attempt to identify the structural requirement of this isoflavonone led to find new chalcones to exhibit the inhibitory activity of IL -5. (omitted)
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