대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.234.2-234.2
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- 2003
Cyclic Aminoalcohols with C-18 Alkenyl Substituents and Their Nanomolar Level-Activities as Tissue Factor Inhibitors
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Yoon, Ung-Chan
(Pusan National University, Department of Chemistry)
;
- Kwon, Hyuk-Chul (Pusan National University, Department of Chemistr) ;
- Cho, Yong-Jin (Pusan National University, Department of Chemistry)
- 발행 : 2003.04.01
초록
Development of new tissue factor (TF) inhibitor is still needed for improved compositions having anticoagulant activity and which can be administed orally or non-intravenously at low doses. Our studies for the development of new TF inhibitors uncovered that aminoalcohols with C-18 alkenyl group, 9-octadecenyl- or 9,12-octadecadienyl groups exhibits in vitro nanomolar level activities. (omitted)
키워드