Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Asymmetric synthesis of (2S, 3R, 4E) 5-Aryl-4-pentene-1,3-diol-2-aminoueras

  • Im, C.U. (College of Pharmacy, Chung-ang University) ;
  • Kim, Y.H. (College of Pharmacy, Chung-ang University) ;
  • Jyung, M.L. (College of Pharmacy, Chung-ang University) ;
  • Lim, C.B. (College of Pharmacy, Chung-ang University)
  • Published : 2003.04.01
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Abstract

(2S 3R. 4E) 5-Aryl-4-pentene-1,3-diol-2-aminoueras had been synthesized for their cytotoxic activity. Pinene was oxidized with KMnO4 to give 2-hydroxy-3-pinanone. which treated with ethyl glycinate to yield iminoglycinate and then reacted with aldehyde derivatives and titanium enolate to afford 3-hydroxy aldol compounds. (omitted)

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