Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.239.1-239.1
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- 2003
A Novel and Highly Potent Non-vanilloid VR Antagonist
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Suh, Young-Ger
(College of Pharmacy, Seoul National University)
;
- Lee, Yong-Sil (Pacific R＆D Center) ;
- Lee, Bo-Young (Pacific R＆D Center) ;
- Min, Kyung-Hoon (Pacific R＆D Center) ;
- Kim, Jin-Kwan (Pacific R＆D Center) ;
- Seung, Ho-Sun (Pacific R＆D Center) ;
- Park, Young-Ho (Pacific R＆D Center)
- Published : 2003.04.01
Abstract
The vanilloid receptor VR has attracted great interest as a sensory transducer for capsaicin. protons, and heat. and as a therapeutic target. On the basis of the previous studies on vanilloid agonists and antagonists. we have looked for non-vanilloid VR antagonists by developing ideal vanilloid equivalents, which might provide the perfect analgesic effects without the side effects caused by vanilloid receptor agonists. (omitted)
Keywords