A new synthesis route to nucleoside: Two-directional synthesis of carbocyclic nucleoside using double [3,3] -sigmatropic rearrangement and double RCM

Extensive efforts in the search of therapeutically useful carbocyclic nucleosides have resulted in a wealth of their synthetic methodologies in racemic and optically active forms. The classical one-directional methods such as linear synthesis and convergent synthesis are the approaches most frequently seen in the literature for the preparation of carbocyclic nucleosides, and their advantages and limitations are well known. (omitted)