Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.248.1-248.1
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- 2003
The inhibiory effect of glycyrrhizin and flavonoids on the reductive metabolism of glucocorticoid by the rat cecal contents.
- Kong, Hye-Sik (College of Pharmacy, Pusan National University) ;
- Kim, In-Ho (College of Pharmacy, Pusan National University) ;
- Kim, Young-Soo (College of Pharmacy, Pusan National University) ;
- Choi, Boh-Im (College of Pharmacy, Pusan National University) ;
- Doh, Min-Ju (College of Pharmacy, Pusan National University) ;
- Kim, Young-Mi (College of Pharmacy, Pusan National University)
- Published : 2003.04.01
Abstract
Glucocorticoids are used most widely for the treatment of inflammatory bowel disease (IBD). For the efficient treatment and reduction of side effects, colon-specific delivery of a glucocorticoid is highly desirable. Previously, we synthesized prednisolone 21-sulfate sodium (PDS) as a colon-specific prod rug of prednisolone (PD) expecting that it might be stable and nonabsorbable in the upper intestine and hydrolyze in the colon to release PD. (omitted)
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