Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.267.1-267.1
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- 2003
Prenylated Flavonoids, Inhibitors of Diacylglycerol Acyltransferase by the root of Sophora flavescens
- Chung, Mi-Yeon (Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology) ;
- Ko, Jeong-Suk (Korea Research Institute of Chemical Technolog) ;
- Ryu, Shi-Young (Department of Biology, Yeungnam University) ;
- Jeune, Kyung-Hee (Department of Biology, Yeungnam University) ;
- Kim, Koan-Hoi (Department of Biology, Yeungnam University) ;
- Rho, Mun-Chual (Department of Biology, Yeungnam University) ;
- Lee, Hyun-Sun (Department of Biology, Yeungnam University) ;
- Kim, Young-Kook (Department of Biology, Yeungnam University)
- Published : 2003.04.01
Abstract
Diacylglycerol acyltransferase (DGAT) is a microsomal enzyme that plays a central role in the metabolism of cellular glycerolipid. Recently, the generation of DGA T-deficient mice has provided a better understanding of triglyceride synthesis and its relationship to obesity. Therefore DGAT is an attractive target for treatments of triglyceride metabolism disorders, such as obesity or hypertriglyceridemia. (omitted)
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