Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.277.2-278
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- 2003
Determination of tiropramide in human plasma by LC/MS/MS
- Lee, Hye-Won (College of Pharmacy, Wonkwang University) ;
- Ji, Hye-Young (College of Pharmacy, Jeonnam University) ;
- Kim, Hee-Hyoun (College of Pharmacy, Jeonnam University) ;
- Kim, Hae-Kyoung (College of Pharmacy, Jeonnam University) ;
- Lee, Yong-Bok (College of Pharmacy, Jeonnam University) ;
- Lee, Hye-Suk (College of Pharmacy, Jeonnam University)
- Published : 2003.04.01
Abstract
A liquid chromatography-tandem mass spectrometric (LC/MS/MS) method for the determination of tiropramide in human plasma was developed. Tiropramide and internal standard, cisapride were extracted from human plasma with MTBE at basic pH. A reverse-phase LC separation was performed on Luna C8 column with the mixture of acetonitrile-ammonium formate (10 mM, pH 4.5) (5:5, v/v) as mobile phase. (omitted)
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