Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.279.1-279.1
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- 2003
Quantification of intact ambroxol tablet using near-infrared spectroscopy
- Kim, Do-Hyung (College of Pharmacy, Dongduk Women′s University) ;
- Lim, Hun-Rang (Korea Food ＆ Drug Administratio) ;
- Woo, Young-Ah (College of Pharmacy, Yeungnam University) ;
- Kim, Hyo-Jin (College of Pharmacy, Yeungnam University) ;
- Kang, Shin-Jung (College of Pharmacy, Yeungnam University) ;
- Choi, Hyun-Chul (College of Pharmacy, Yeungnam University) ;
- Choi, Han-Gon (College of Pharmacy, Yeungnam University)
- Published : 2003.04.01
Abstract
NIR reflectance spectroscopy, using a fiber-optic probe was used to determine rapidly and non-destructively the content of ambroxol in intact ambroxol 30 mg (nominal content 12.5％ m/m ambroxol) tablets by collecting NIR spectra in range 1100 - 1750 nm and using PLSR calibration method. The tablets (10.3 - 15.9％ m/m ambroxol, i.e., 82 - 127％ of the nominal label content) were used 7 calibration set and 5 validation set. (omitted)
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