Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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In vitro metabolism of a new protective agent, KR-31543 in human liver microsomes

  • Ji, Hye-Young (College of Pharmacy, Wonkwang University) ;
  • Kim, Sook-Jin (AgroPharma Research Institute, DonbuHannong Chemical C) ;
  • Lee, Hong-Il (AgroPharma Research Institute, DonbuHannong Chemical C) ;
  • Lee, Seung-Seok (AgroPharma Research Institute, DonbuHannong Chemical C) ;
  • Lee, Dong-Ha (AgroPharma Research Institute, DonbuHannong Chemical C) ;
  • Lim, Hong (AgroPharma Research Institute, DonbuHannong Chemical C) ;
  • Lee, Hye-Suk (AgroPharma Research Institute, DonbuHannong Chemical Co)
  • Published : 2003.04.01
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Abstract

The purpose of this paper was to identify the metabolic pathway of a new neuroprotective agent, KR-31543 for ischemia-reperfusion damage in human liver microsomes and characterize cytochrome P450 (CYP) enzymes involved in the in vitro metabolism of KR-31543 generates two metabolites in human liver microsomes : M1, N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine and M2, hydroxy-KR-31543. (omitted)

Keywords