대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.290.1-290.1
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- 2003
Determination of nucleosides in human urine by high-performance liquid chromatography with electrospray ionization mass spectrometry(LC/ESI-MS)
- Lee, Sang-Hee (Korea Institute of Science and Technology) ;
- Jung, Byung-Hwa (Korea Institute of Science and Technolog) ;
- Kim, Sun-Yeou (Korea Institute of Science and Technolog) ;
- Kim, Ho-Cheol (Korea Institute of Science and Technolog) ;
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Chung, Bong-Chul
(Korea Institute of Science and Technology)
- 발행 : 2003.04.01
초록
Oxidative DNA damage has been associated with many disease. Quantation of DNA adducts is considered to be a useful biomarker of oxidative DNA damage because its formation can also be induced by oxidative stress. Extensive efforts have been taken to identify the analytical methods for minimizing the artifactual formation of oxidative DNA damage. We have done direct analysis of DNA adducts using LC/ESI-MS without urine sample extraction. (omitted)
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