Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Modulation of electroosmosis using penetration enhancers

  • Kim, Su-Youn (College of pharmacy, Sookmyung Women′s University) ;
  • Lee, Yeon-Joo (College of pharmacy, Sookmyung Women′s University) ;
  • Lee, Hyung-Won (College of pharmacy, Sookmyung Women′s University) ;
  • Lee, Hyo-Jung (College of pharmacy, Sookmyung Women′s University) ;
  • Lee, Seung-Yeon (College of pharmacy, Sookmyung Women′s University) ;
  • Youe, Jee-Sun (College of pharmacy, Sookmyung Women′s University) ;
  • Oh, Seaung-Youl (College of pharmacy, Sookmyung Women′s University)
  • Published : 2003.04.01
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Abstract

Electroosmotic flux during iontophoresis originates due to the net negative charge of the current passing channels (pores) in skin at physiological pH (pH 7.4). Thus, the channels are permselective to cations, and this causes the convective solvent flow from anode to cathodal direction. This solvent flow facilitates the flux of cations (from anode), inhibits that of anions (from cathode), and enables theenhanced transport of neutral, polar solutes. (omitted)

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