대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.300.3-301
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- 2003
Expression of O-acetyl disialoganglioside synthase in experimental rat and human liver fibrosis
- Lee, Sung-Hee (College of Pharmacy, Wonkwang University) ;
- Choi, Jeong-Yong (Division of Biological Sciences, Chonbuk National University) ;
- Park, Eun-Jeon (Yonsei University College of Medicin) ;
- Zhao, Yu-Zhe (Yonsei University College of Medicin) ;
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Park, Young-Nyun
(Yonsei University College of Medicin)
;
- Chae, Keon-Sang (Yonsei University College of Medicin) ;
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Sohn, Dong-Hwan
(College of Pharmacy, Wonkwang University)
- 발행 : 2003.04.01
초록
The activation of the hepatic stellate cell (HSC) is a key step in liver fibrogenesis. Utilizing large scale sequencing of a 3' -directed cDNA library, we investigated expression profiles of quiescent and activated rat HSCs. During the activation process, O-acetyl disialoganglioside synthase (OAcGD3S) was identified as one of the significant upregulated factors. Upregulation of OAcGD3S in cultured HSCs was confirmed by both northern and western blot analyses. (omitted)
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