대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Determination of Levofloaxcin in Human Serum by High-Performance Liquid Chromatography/Diode Array Detector and its Application to Pharmacokinetics of Levofloxacin in Volunteers

  • Kim, Seung-Yong (Toxicology Lab., Korea Institute of Science and Technology) ;
  • Chung, Youn-Bok (College of Pharmacy, Chungbuk National University) ;
  • Kwon, Oh-Seung (Toxicology Lab., Korea Institute of Science and Technology)
  • 발행 : 2003.04.01
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초록

A simple, specific and sensitive method for the determination of levofloaxcin (LFX) in human serum was developed by a high performance liquid chromatography/diode array detector and applied to pharmacokinetic study of LFX in human volunteers. This method involves several steps such as precipitation with acetonitrile, extraction with methylene chloride, evaporation, and concentration, using 0.5ml of the serum. (omitted)

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