대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.311.1-311.1
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- 2003
Dose-Independent Pharmacokinetics of a New Reversible Proton Pump Inhibitor, KR-60436, after Intravenous and Oral Administration to Rats: Gastrointestinal First-Pass Effect
- Yu, Su-Yeon (College of Pharmacy, Seoul National University) ;
- Shin, Jee-Hyun (College of Pharmacy, Seoul National University) ;
- Bae, Soo-Kyung (College of Pharmacy, Seoul National University) ;
- Kim, Eun-Jung (College of Pharmacy, Seoul National University) ;
- Kim, Yoon-Gyoon (College of Pharmacy, Seoul National University) ;
- Kim, Sun-Ok (College of Pharmacy, Seoul National University) ;
- Lee, Dong-Ha (College of Pharmacy, Seoul National University) ;
- Lim, Hong (College of Pharmacy, Seoul National University) ;
- Lee, Myung-Gull (College of Pharmacy, Seoul National University)
- 발행 : 2003.04.01
초록
Dose-independent pharmacokinetic parameters of KR-60436, a new proton pump inhibitor, were evaluated after an intravenous, iv (5, 10, and 20 mg/kg) and an oral (20, 50, and 100 mg/kg) administration to rats. The hepatic, gastric, and intestinal first-pass effects were also measured after iv, intraportal (ip), intragastric (ig), and intraduodenal (id) administration at a dose of 20 mg/kg to rats. (omitted)
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