Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Polyunsaturated fatty acids regulate APP metabolism.

  • Yeon, Seung-Woo (ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd.) ;
  • Kim, Tae-Yong (ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd.)
  • Published : 2003.10.01
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Abstract

Polyunsaturated fatty acids (PUFAs) play many important physiological roles on cellular process through the regulations of intracellular signaling. Recent clinical studies suggest that PUFAs such as n-3 fatty acids (docosahexaenoic acid, 22:6 and a-lnolenic acid, 18:3) may reduce the risk of incident Alzheimer's disease (AD). And also the reports regarding the decrease of n-3 fatty acids in AD brain support the correlation between PUFAs and AD. AD is a neurodegenerative disorder with pathological hallmarks of amyloid plaques and neurofibrillary tangles. (omitted)

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