Neuroprotective effects of Hexane fraction of M61 on Delayed Neuronal Death after Transient global Ischemia in Gerbil Hippocampus

  • Kim, Haw-jung (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Kang, Hoon-Je (Natural Products Research Institute, College of Pharmacy, Seoul National Universit) ;
  • Mar, Woong-Chon (Natural Products Research Institute, College of Pharmacy, Seoul National University)
  • Published : 2003.10.01

Abstract

Several lines of recent evidences have shown that several pro-inflammatory genes or mediators, such as inducible nitric oxide synthase (iNOS)are strongly expressed in the ischemic brain. Inflammation is now recognized as a significant contributing mechanism in cerebral ischemia because anti-inflammatory compounds or inhibitors of iNOS have been proven to reduce ischemic brain damage. In iNOS assay, hexane fraction of M61 inhibited NO (iNOS IC50, 0.7${\mu}$g/ml). In vivo study was carried out to evaluate neuroprotective effect of hexane fraction of M61 after transient global ischemia using Mongolian gerbil ischemia model. (omitted)

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