Melatonin increases cell proliferation in the dentategyrus of maternally-separated rats

  • Jung, Kyung-Hee (Graduate School of Obesity Science, Dongduk Women′s University) ;
  • Jung, Eun-young (Department of Food and Nutrition, Dongduk Women′s University) ;
  • Kim, Mi-Ja (Graduate School of Obesity Science, Dongduk Women′s University) ;
  • Kim, Hye-Kyung (Department of Food & Biotechnology, Hanseo University) ;
  • Kim, Yong-Ok (Department of Food and Nutrition, Dongduk Women′s University) ;
  • Chang, Un-Jae (Department of Food and Nutrition, Dongduk Women′s University) ;
  • Yim, Sung-Vin (Department of Pharmacology, Kohwang Medical Research Institute, College of Medicine, Kyung Hee University)
  • Published : 2004.05.01

Abstract

Melatonin in mammals, produced by the pineal gland and elsewhere, has shown antioxidant and neuroprotective properties in neuronal cells. We investigated whether melatonin would increase newly-born cells (cell proliferation) in the dentate gyrus of maternally-separated rats. To examine the effect of melatonin on cell proliferation of the dentate gyrus in maternally-separated rats, 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry was performed.(omitted)

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