Structure Control of Polysaccharide Derivatives for Efficient Enantioseparation by HPLC

Chromatographic separation of enantiomers by high-performance liquidchromatography (HPLC) has considerably advanced in the past two, and many optically active polymers have been developed to be usedaschiral stationary phases (CSP). Among many CSPs, cellulose-andamylose-based CSPs are most attractive from the viewpoints of theirwide applicability and easy availability. The polysaccharides are readily modified to ester and carbamates. The derivatives have been used as CSPs after being coated on macroporus silica gel. Here, the CSPs based on phenylcarbamate derivatives of these two polysaccharides will be mainly discussed. The immobilization of the derivatives on silica gel will also be discussed.