Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)

The Polymer Society of Korea (한국고분자학회)
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NOVEL CATIONIC POLYMERS DESIGNED FOR NON-VIRAL GENE DELIVERY

  • Zhong Zhiyuan (Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology (BMTI), Faculty of Science and Technology, University of Twente) ;
  • Lin, Chao (Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology (BMTI), Faculty of Science and Technology, University of Twente) ;
  • Song, Yan (Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology (BMTI), Faculty of Science and Technology, University of Twente) ;
  • Lok Martin C. (Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Science (UIPS), Utrecht University) ;
  • Jiang Xulin (Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Science (UIPS), Utrecht University) ;
  • Christensen Lane V. (Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah) ;
  • Engbersen Johan F.J. (Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology (BMTI), Faculty of Science and Technology, University of Twente) ;
  • Kim, Sung-Wan (Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah) ;
  • Hennink Wim E. (Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Science (UIPS), Utrecht University) ;
  • Feijen Jan (Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology (BMTI), Faculty of Science and Technology, University of Twente)
  • Published : 2006.10.13
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Abstract

Gene therapy holds great promise for treating various forms of diseases with a genetic origin including cystic fibrosis, different forms of cancer, and cardiovascular disorders. The clinical use of gene therapy treatments is however restricted, mainly because of the absence of safe and efficient gene delivery technologies. In our group, with an aim of developing efficient and nontoxic polymeric gene delivery systems, several novel types of polymeric gene carriers have been designed, synthesized, and evaluated. Herein, I will mainly present our recent work on low molecular weight linear PEI-PEG-PEI triblock copolymers, degradable hyperbranched poly(ester amine)s, and reduction-sensitive poly(amido amine)s.

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