Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)

The Polymer Society of Korea (한국고분자학회)
권호 표지

A New Class of Sol-Gel Transition Hydrogels for Macromolecular Delivery

  • Lee, Yu-Han (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
  • Park, Sung-Young (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
  • Chung, Hyun-Jung (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
  • Park, Tae-Gwan (Department of Biological Sciences, Korea Advanced Institute of Science and Technology)
  • Published : 2006.10.13
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Abstract

A new series of PEO-PPO-PEO and PPO-PEO-PPO copolymers having several hydroxyl groups on the PPO chain segment were synthesized, further modified with various poly(lactic acid) PLA oligomeric chains to confer physical stability after thermo-gelation in the body fluid. Gel stability was endowed by either increasing hydrophobic interaction between PLA chains or inducing stereocomplex formation between enatiomeric isomers of PLA chains. Macromolecular drugs were incorporated within the gels and their release patterns were investigated using Pluronic F127 as a control.

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