Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)

The Polymer Society of Korea (한국고분자학회)
권호 표지

Chemical Modification of Chitosan as Gene Carriers In Vitro and In Vivo

  • Kim, Tae-Hee (School of Agricultural Biotechnology, Seoul National University) ;
  • Jin, Hua (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Hyun-Woo (College of Veterinary Medicine, Seoul National University) ;
  • Cho, Myung-Haing (College of Veterinary Medicine, Seoul National University) ;
  • Nah, Jae-Woon (Department of Polymer Science and Engineering, Sunchon National University) ;
  • Cho, Chong-Su (School of Agricultural Biotechnology, Seoul National University)
  • Published : 2006.10.13
Download PDF
⟨ Previous Next ⟩

Abstract

Chitosan has been investigated as a non-viral vector because it has several advantages such as biocompatibility, biodegradability and low toxicity with high cationic potential. However, low specificity and low transfection efficiency of chitosan as a DNA carrier need to be overcome for clinical trials. In this study, chemical modification for enhancement of cell specificity and transfection efficiency was investigated. Also, the chitosan derivative formulations in vivo were included.

Keywords