Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)

The Polymer Society of Korea (한국고분자학회)
권호 표지

Sustained Protein Delivery System using Core/shell Nanoparticles

  • Oh, Keun-Sang (Department of Polymer Science and Engineering, Hannam University) ;
  • Koo, Hyoung-Mo (Department of Polymer Science and Engineering, Hannam University) ;
  • Yuk, Soon-Hong (Department of Polymer Science and Engineering, Hannam University)
  • Published : 2006.10.13
Download PDF
⟨ Previous Next ⟩

Abstract

A novel preparation method for core/shell nanoparticles with protein drug-loaded lipid core was designed and characterized. The lipid core is composed of lecithin and protein drug and the polymeric shell is composed of Pluronics (poly (ethylene oxide)-poly (propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127 For the application of core/shell nanoparticles as a protein drug carrier, lysozyme and Vascular Endothelial Growth Factor (VEGF) were loaded into the core/shell nanoparticles by electrostatic interaction and the drug release pattern was observed by manipulating the polymeric shell.

Keywords