Proceedings of the Polymer Society of Korea Conference (한국고분자학회:학술대회논문집)

The Polymer Society of Korea (한국고분자학회)
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Nano-Hydroxyapatite Modified by Grafting Polylactide and its Tissue Engineering Application

  • Zhuang, Xiuli (State Key Laboratory of Polymer Physics and chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences) ;
  • Zhang, Peibiao (State Key Laboratory of Polymer Physics and chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences) ;
  • Qiu, Xueyu (State Key Laboratory of Polymer Physics and chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences) ;
  • Chen, Xuesi (State Key Laboratory of Polymer Physics and chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences) ;
  • Jing, Xiabin (State Key Laboratory of Polymer Physics and chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences)
  • Published : 2006.10.13
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Abstract

PLLA grafted Hydroxyapatite / polylactide (g-HA/PLA) composites were prepared by three grafting methods. The modified particles (p-HA) were dispersed more uniformly in the PLLA matrix than pure n-HA. The p-HA/PLLA composites exhibited better mechanical properties and thermal stability than the n-HA/PLLA composites. The composites also demonstrated improved cell compatibility due to the good biocompatibility of the HAP nanoparticles and the more uniform distribution of the PLLA-grafted HAP nanoparticles on the film surface. All of these results indicated that the p-HAP/PLLA nano-composites might have a promising medical application in bone repair and in bone tissue-engineering.

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