Proceedings of the KSME Conference (대한기계학회:학술대회논문집)

The Korean Society of Mechanical Engineers (대한기계학회)
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IN-VITRO CHARACTERIZATION OF THE THROMBOTIC POTENTIAL OF WHOLE BLOOD USING AN IMPEDANCE METHOD

  • Granaderos, Carlo (Division of Mechanical and Aerospace System Engineering, Chonbuk National University) ;
  • Park, Joong-Chun (Division of Mechanical and Aerospace System Engineering, Chonbuk National University) ;
  • Pak, Bock-Choon (Division of Mechanical and Aerospace System Engineering, Chonbuk National University) ;
  • Kim, Cheol-Sang (Division of Electronics and Information Engineering, Chonbuk National University) ;
  • Cho, Young-I (Department of Mechanical Engineering and Mechanics, Drexel University)
  • Published : 2007.05.30
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Abstract

This study presents an impedance method of in-vitro characterization of the thrombotic potential of whole blood. Whole blood samples of 0.2 cc were put into a micro-cell with embedded three electrodes immediately after venepuncture at $37^{\circ}C$. Anti-coagulated blood samples were also collected for hematocrit and blood viscosity analyses. The rate of change of electron flow was measured, which indicates the inverse of the thrombotic potential. A sudden decrease in the rate of change of electron flow was observed at a time equal to approximately 110 seconds. This sudden decrease was significantly delayed in anti-coagulated samples. After the sudden decrease, the rate continued to decrease, reaching a minimum value in unadulterated samples while the change in the rate in the anti-coagulated ones was found rather moderate. Based on these preliminary findings, the present method may be of used as a new tool for the diagnosis of the thrombotic potential of whole blood.

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