Primary Cellular Study of Phagocytosis for Alzheimer Disease Diagnosis

알츠하이머 조기 진단을 위한 변형된 대식세포의 기초적 연구

  • Cho, Jung-Min (Electronics and Telecommunication Research Institute) ;
  • Chae, Cheol-Joo (Electronics and Telecommunication Research Institute) ;
  • Kang, Jae-Min (Electronics and Telecommunication Research Institute) ;
  • Kim, Kwan-Su (Electronics and Telecommunication Research Institute) ;
  • Song, Ki-Bong (Electronics and Telecommunication Research Institute)
  • Published : 2010.06.16

Abstract

Alzheimer disease is a progressive neurodegenerative disease of the aged, characterized by memory loss and dementia. For diagnosis of Alzheimer disease we have simply modified macrophage with amyloid beta bonded with different molecules. Modified Macrophage was observed with microscope for co-localization of amyloid beta molecule. For this experiment we used fluoroscene labeling substances. The macrophage was modified also with cell staining method. For cell staining method was used avidin-biotin reaction principles. All experiments were carried out on poly-L-lysine coated and sterilized glass substrates. In the presentation we will show the further investigations and applications with modified macrophage.

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