Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)

The Plant Resources Society of Korea (한국자원식물학회)
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Anti-Oxidant and Anti-Inflammatory Complex Health Functional Analysis of Chinese Resource Plant Boehmeria, Carlemannia and Clausena

중국 자원식물 보메리아, 칼라마니아, 클로세나의 항노화 항염 복합 건강관리 기능성 연구

  • Jin Mun (Kangnam University, National Institute of Medical Welfare) ;
  • Jung Min Lee (Kangnam University, National Institute of Medical Welfare) ;
  • Je Heon Lee (Kangnam University, National Institute of Medical Welfare) ;
  • Dong Hyun Lee (Kangnam University, National Institute of Medical Welfare) ;
  • Seo Yeon Choi (Kangnam University, National Institute of Medical Welfare) ;
  • Ye Lim Jung (Kangnam University, National Institute of Medical Welfare) ;
  • Kyung-A Choi (Kangnam University, National Institute of Medical Welfare)
  • 문진 (강남대학교 의료복지연구소) ;
  • 이정민 (강남대학교 의료복지연구소) ;
  • 이제헌 (강남대학교 의료복지연구소) ;
  • 이동현 (강남대학교 의료복지연구소) ;
  • 최서연 (강남대학교 의료복지연구소) ;
  • 정예림 (강남대학교 의료복지연구소) ;
  • 최경아 (강남대학교 의료복지연구소)
  • Published : 2023.04.27
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Abstract

Ageing has been known to be deeply related to oxidative activities. Furthermore, inflammation is a response initiated by conditions such as infection and injury. It has been known that complex connections occur between oxidative stress and the inflammatory response, however underlying mechanism needs to be investigated. Chinese resource plants have been widely used as functional food and medicine for a long time, however it is not studied well how many of these resource plants work. We first decided testing anti-oxidant and anti-inflammatory activities with 95% ethanol extracts of the chinese resource plants, Boehmeria pilosinscula (Blume) Hassk., Carlemannia tetragona Hook f. and Clausena emarginata C.C.Huang. To measure anti-oxidant activity, we performed DPPH assay in Raw264.7 cells with 95% ethanol extracts. Clausena extracts showed significantly higher anti-oxidant activity than those of Boehmeria and Carlemannia. We then performed Nitric Oxide assay to measure the inflammation suppression levels with 95% ethanol extracts of these plants. Clausena extracts showed significantly higher suppression of nitric oxide production than those of Boehmeria and Carlemannia. This indicates that inflammation levels are significantly reduced by Clausena. After measuring anti-oxidant and anti-inflammatory activities, we then performed MTT assay to measure the cell survival rate of Raw264.7 cells treated with these extracts. Boehmeria showed much more cell survival rate than Carlemannia and Clausena. Taken together, this result suggests that Clausena extracts have more anti-oxidant and antiinflammatory activities than Boehmeria and Carlemannia, while Boehmeria extracts have more cell survival rate than Carlemannia and Clausena.

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Acknowledgement

본 연구는 강남대학교 대학교육혁신단 창의융합교육센터 2023년 K-프로젝트 사업의 지원에 의해 이루어진 결과로 이에 감사드립니다.