Studies on Chemotherapeutics for Fasciola hepatica and Eurytrema pancreaticum -The Vermicidal Effects of Hexachlorophene, Bithionol and Dithiazanine Iodide on Fasciola hepatica in Vitro-

간질(肝蛭) 및 췌질(膵蛭)의 화학적(化學的) 구제제(驅除劑)에 관(關)한 연구(硏究) -Hexachlorophene, Bithionol 및 Dithiazanine iodide의 시험관내(試驗管內)에서의 간질살충효력(肝蛭殺蟲效力)에 관(關)한 비교실험(比較實驗)-

Hexachlorophene, Bithionol and Dithiazanine iodide were used to examine the vermicidal effect on Fasciola hepatica in vitro. A kymographic study was performed to investigate the motility of Fasciola hepatica under the influence of these drugs. Following conclusions were made: 1) With 10,000 : 1 solution; exhibited the vermicidal effect on Fasciola hepatica, Hexachlorophene in 5 minutes, Bithionol in 10 minutes, and Dithiazanine, iodide in 40 minutes, respectively. 2) With 100,000 : 1 solution; exhibited the vermicidal effect on Fasciola hepatica, Hexachlorophene in 20 minutes and Bithionol in 30minutes. In the case of Dithiazanine iodide the stimulation upon the fluke continued for 120 minutes. 3) With 1,000,000 : 1 solution; exhibited the vermicidal effect on Fasciola hepatica, Hexachlorophene in 50 minutes and Bithionol in 80 minutes. In the case of Dithiazanine iodide the stimulation upon the fluke continued for 120 minutes. 4) With 10,000,000 : 1 solution; the only Hexachlorophene showed the vermicidal effect on Fasciola hepatica. In the case of Bithionol and Dithiazanine iodide the slight stimulation upon the fluke continued for 120 minutes.