The Korean Journal of Physiology

The Korean Physiological Society (대한생리학회)
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Variations of SCN Space in Metabolic Acidosis and Alkalosis in Rabbits

대사성 산증 및 알칼리증에 있어서 SCN 공간의 변화

  • Earm, Yung-E (Department of Physiology, Seoul National University College of Medicine) ;
  • Nam, Kee-Yong (Department of Physiology, Seoul National University College of Medicine)
  • 엄륭의 (서울대학교 의과대학 생리학 교실) ;
  • 남기용 (서울대학교 의과대학 생리학 교실)
  • Published : 1971.12.01
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Abstract

Thiocyanate space was determined in 23 bilaterally nephrectomized rabbits in acute metabolic acidosis and alkalosis. Acid-base disturbances were induced by the infusion of 0.3 N HCI or 0.3 N NaOH solution intravenously with the rate of 1 ml/min for 40 to 60 minutes. The blood pressure was monitored throughout the experiment and no changes in blood pressure was confirmed. The following results were obtained. 1. In the saline infused control rabbits, PH was 7.385 with negligible change in pH after the infusion, SCN space was 23.6% of body weight. 2. In the metabolic acidosis group, pH dropped from 7.417 to 7 130 and SCN space was 22.8% of body weight and suggested a negligible change in the extracellular space volume. 3. In the metabolic alkalosis group, pH increased from 7.393 to 7.478 and SCN space was 25.7% of body weight which confirmed a significant increase in the extracellular space volume.

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