Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Synthesus of DL-1-Amino Alkyl Phosphonic Acids and Their Derivatives (II)

DL-1-Amino Alkyl Phosphonic Acid 와 그 유도체들의 합성 (ll)

  • Kyung Yeon Cho (Department of Chemical Engineering, College of Science and Engineering, Korea Unversity) ;
  • Duck Chan Kim (Department of Chemical Engineering, College of Science and Engineering, Korea Unversity) ;
  • Yong Joon Kim (Department of Chemical Engineering, College of Science and Engineering, Korea Unversity)
  • 조경연 (고려대학교 이공대학 화학공학과) ;
  • 김덕찬 (고려대학교 이공대학 화학공학과) ;
  • 김용준 (고려대학교 이공대학 화학공학과)
  • Published : 1971.10.30
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Abstract

Six previously unreported N-acylated-DL-1-amino alkyl phosphonic acids were prepared; N-Acetyl-DL-1-amino-3-methyl butyl phosphonic acidN-Benzoyl-DL-1-amino-2-methyl propyl phosphonic acidN-Benzoyl-DL-1-amino-3-methyl butyl phosphonic acidN-Benzoyl-DL-1-amino-2-methyl butyl phosphonic acidN-Acetyl-DL-1-amino-2-methyl propyl phosphonic acidN-Acetyl-DL-1-amino-2-methyl butyl phosphonic acidThe first four compounds were characterized, and the last two compounds were obtained in the crude oil state. The above three DL-1-amino-alkyl phosphonic acid were synthesized from iso-valeric acid, iso-caproic acid and ${\beta}$-methyl valeric acid using Hell-Volhard-Zelinsky reaction, the condensation reaction with triethyl-phosphite and the modified Curtius Reaction. Iso-caproic acid and ${\beta$-methyl valeric acid were prepared by the conventional methods.

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