Mutagenicity of Nitrofuran, Nitroimidazole and Nitrothiazole Derivatives on Salmonella/Microsome System

Nitrofuran, Nitroimidazole 및 Nitrothiazole 유도체들의 Salmonella/Microsome System에 대한 돌연변이 유발성

Using Ames'Salmonella/microsome system, mutagenicity of antirichomonal nitrofuran, nitroimidazole, and nitrothiazole derivatives was examined. Nitrofurantoin, nifuratel, furazolidone, metronidazole, nimorazole, ornidazole, and aminitrozole showed potent mutagenicity en $TA_100$ strain which is a base substitute mutant and contains R-factor plasmid pKM101 without microsomal enzyme activation. In addition, nifuratel, furazolidone, metronidazole, and ornidazole also induced frameshift mutation in $TA_98$ strain.