약학회지 (YAKHAK HOEJI)
- 제23권2호
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- Pages.81-94
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- 1979
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Rifampicin-Polyvinylpyrrolidone 공침물에 관한 생물약제학적 연구
A Biopharmaceutical Study on Rifampicin-Polyvinylpyrrolidone Coprecipitate
초록
Rifampicin-polyvinylpyrrolidone coprecipitates were prepared by the solvent method to increase the solubility and dissolution rate, thereby improving absorption of rifampicin. It was found that the solubility and dissolution rate were greater with the 1 : 5 (w/w) coprecipitate than with the pure drug, physical mixtures or coprecipitates of any other ratio of the two components. The blood concentration data in non-fasted rats showed that the extent of absorption of rifampicin were significantly enhanced following the oral administration of the 1 : 5 coprecipitate; The area under the serum concentration curve (0-8hr) was 1.3 times greater with the 1 : 5 coprecipitate than with the pure drug. The blood concentration reached its peak (4. 38
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