Enhancement of Dissolution from Pharmaceutical Preparation of Hydrophobic Drugs ( I ) -Characteristics of Sulpiride-Polyethylene Glycol Coprecipitates-

Data from IR spectroscopy and X-ray diffractometry were used for the characterization of sulpiride polyethylene glycol coprecipitates related with polymorphism of sulpiride. Sulpiride Form II transformed to Form I during coprecipitating with polyethylene glycol and the transformation rate is increased in proportion to molecular size of polyethylene glycol and the content of polyethylene glycol in coprecipitate.